By IMBA-Exchange on The CapitalPhoto from the sourceBlockchain technologies can do a lot, and IMBA-Exchange constantly talks about this in its articles. Many cryptocurrencies have their own POW algorithms, with which miners can mine cryptocurrencies using powerful computing technology (powerful video cards or ASIC hardware).As we know, coronavirus infection is now spreading in the world. Various scientists and doctors from all over the world are trying to find a way to treat this infection.A few days ago, NVIDIA and other major players in the global market joined the Folding@Home project to fight the coronavirus.Folding@Home is an application that allows you to combine computers into an international network that uses distributed computing power to solve complex computing tasks.NVIDIA encourages all owners of gaming PCs to download the Folding@Home app to use the computer in their free time to fight this dangerous disease, which has already claimed many lives.Screenshot from the sourceAll viruses have proteins that they use to suppress our immune system and reproduce.To help fight the coronavirus, specialists at Folding@Home are using computer simulations to find out how these viral proteins work and how specialists can develop therapeutics to stop viruses.In the Folding@Home project, simulation is run several biochemical processes, during which the virus enters the cells of the human body. This is expected to help understand the nature of the virus and develop a cure for it faster. Computer modeling of such processes requires a huge amount of computing resources, and the more such resources, the more likely it is to find treatment methods.The Folding@Home application allows you to combine computers into an international network that uses distributed computing power to solve complex computing tasks — gaming GPUs are quite suitable for these purposes, and mining equipment for these tasks is even better because of the efficiency and speed of information processing for miners are much higher. For such processes, as in mining, CPUs and GPUs are used. Every user who runs such an app can disable the app at any time and restore the power of their hardware.So let’s talk a little bit about the Folding@Home app. Information about the app is taken from the official website of [email protected] — WHAT WE’RE DOING AND HOW YOU CAN HELP IN SIMPLE TERMSMarch 15, 2020by Greg BowmanTL;DR: We’re simulating the dynamics of COVID-19 proteins to hunt for new therapeutic opportunities. Scroll to the bottom of the page to see a list of ways you can help.Proteins are molecular machines that perform many functions we associate with life. They sense the environment (e.g. in taste and smell), perform work (e.g. muscle contraction and breaking down food), and play structural roles (e.g. your hair). They are made of a linear chain of chemicals called amino acids that, in many cases, spontaneously “fold” into compact, functional structures. Much like any other machine, it’s how a protein’s components are arranged and move that determine the protein’s function. In this case, the components are atoms.Viruses also have proteins that they use to suppress our immune systems and reproduce themselves.To help tackle coronavirus, we want to understand how these viral proteins work and how we can design therapeutics to stop them.There are many experimental methods for determining protein structures. While extremely powerful, they only reveal a single snapshot of a protein’s usual shape. But proteins have lots of moving parts, so we really want to see the protein in action. The structures we can’t see experimentally may be the key to discovering a new therapeutic.Using football as an analogy for the experimental situation, it’s as if you could only see the players lined up for the snap (the single arrangement the players spend the most time in) and were blind to the rest of the game.Seeing a single structure of a protein (left) is like seeing players lined up for the snap in football. Important information, but a lot missing too. The protein structure shows a sphere for each atom (blue) and red arrows highlighting the one drug binding site in this protein.Our specialty is in using computer simulations to understand proteins’ moving parts. Watching how the atoms in a protein move relative to one another is important because it captures valuable information that is inaccessible by any other means.Taking the experimental structures as starting points, we can simulate how all the atoms in the protein move, effectively filling in the rest of the game that experiments miss.https://medium.com/media/de8f12b2d2c1960c922cd1d6335ad21a/hrefA movie capturing how the protein shown before moves is like getting to watch the whole football game. In this case, we see a pocket form that was absent in the experimental structure.Doing so can reveal new therapeutic opportunities. For example, in our recent paper, we simulated a protein from Ebola virus that is typically considered ‘undruggable’ because the snapshots from experiments don’t have obvious druggable sites. But, our simulations uncovered an alternative structure that does have a druggable site. Importantly, we then performed experiments that confirmed our computational prediction, and are now searching for drugs that bind this newly discovered binding site.An experimental structure of an Ebola protein doesn’t have obvious druggable sites (no deep pockets among the atoms shown as spheres).https://medium.com/media/9a97bdfe475c789fc77a3fcbfbaf4046/hrefOur simulations captured a motion that creates a potentially druggable site in this Ebola protein. Instead of showing spheres for each atom, this cartoon shows a ribbon tracing the linear chain of amino acids (chemicals) the protein is made of.We want to do the same thing with coronavirus, and you can help! In fact, there are a number of ways you can help, and they’re not mutually exclusive.Downloading Folding@home and helping us run simulations is the primary way to contribute. These calculations are enormous and every little bit helps! Each simulation you run is like buying a lottery ticket. The more tickets we buy, the better our chances of hitting the jackpot. Usually, your computer will never be idle, but we’ve had such an enthusiastic response to our COVID-19 work that you will see some intermittent downtime as we sprint to setup more simulations. Please be patient with us! There is a lot of valuable science to be done, and we’re getting it running as quickly as we can.If you don’t have computers to contribute or are feeling particularly generous, you can also make donations through Washington University in St. Louis. These funds are used for a number of purposes, including: 1) supporting our software engineering and server-side hardware (particularly important right now as we scale up rapidly!) and 2) buying compounds to test experimentally based on insight from our simulations.Of course, please take precautions to help prevent the spread of the virus by washing your hands, social distancing, etc. Doing so helps sustain the medical system and buys scientists time to hunt for therapies.Download and run the Folding@Home app and let’s save our world from diseases together!Thus, we encourage all miners and everyone who wants to use the Folding@Home software to join forces in the fight against coronavirus!BEST REGARDS, YOUR IMBA-EXCHANGE TEAM!Material developed by IMBA-ExchangeThe Capitalhttps://medium.com/media/3b6b127891c5c8711ad105e61d6cc81f/hrefMiners VS Coronavirus was originally published in The Capital on Medium, where people are continuing the conversation by highlighting and responding to this story.